The use of DIM in an animal study at hundreds of times the amount provided in dietary supplements produced no adverse effects. Are DIM supplements safe? DIM has been taken as a dietary supplement for many years without any reports of adverse effects, and DIM’s safety has been evaluated. DIM is by far the preferable supplement.) This means I3Cmust be taken at a much higher amount and can undergo unpredictable and undesirable chemical reactions in your stomach or colon. I3C is an unstable precursor that requires activation in the stomach to be converted into DIM. (DIM provides many advantages over indole-3-carbinol, another cruciferous phytochemical available as a dietary supplement (I3C). DIM supplements need to provide an effective delivery system, preferably one that has undergone testing in animal and clinical settings. What is the best way to increase DIM & “good” estrogen? DIM is extremely insoluble and poorly absorbed without a biodelivery vehicle. Research has determined that harmful alterations in the “good estrogen” to “bad estrogen” ratio are responsible for the development of certain cancers in men and women. In men, estrogen assists in the production of healthy and viable sperm. This estrogen conversion from testosterone, with further metabolism of estrogen into estradiol, estrone, and the hydroxylation of “good” and “bad” estrogens, occurs in the liver, the same place estrogen metabolism occurs in women. In fact, it’s believed that in men, estrogen is converted from testosterone, the most abundant male sex hormone. Is DIM for women only, since it decreases the harmful effect of estrogen? While estrogen is generally thought of as a female hormone, men need and produce small amounts of estrogen, too. These enzymes are important for healthy estrogen metabolism that reduces the risk of cancer development. DIM has also been shown to enhance the activity of enzymes found in certain pathways in the liver. Scientists have determined DIM actually inhibits cancer cell growth. Is there any research that shows DIM improves health? Many impressive studies have led to understanding DIM’s effect on cancer. DIM supplementation specifically promotes beneficial estrogen metabolism and helps restore a healthy hormonal balance. This is where DIM enters the picture-DIM can successfully increase the ratio of “good” to “bad” estrogen. Researchers have speculated that increasing production of this “good” estrogen would be very beneficial. Scientists have discovered that 2-methoxyestrogens, one of several types of estrogen, can actually inhibit the growth of malignant tumors. Also, certain estrogen metabolites are directly linked to the development of several types of cancer. Women with higher levels of estrogen circulating in their bloodstreams have a higher incidence of breast cancer. However, excessive prolonged exposure to estrogen is also associated with serious health problems. Estrogen has many beneficial activities in the human body: regulating the growth and development of reproductive organs, controlling the growth of the uterine lining, assisting in promotion of fertilization and pregnancy, maintaining the normal structure of skin and blood vessels, maintaining bone structure, and regulating various metabolic processes. How does DIM work? DIM has a direct effect on the hormone estrogen and how it is metabolized. Once these enzymes are exposed to stomach acid, a compound called indole-3 carbinol (I3C) is formed which, in turn, yields DIM. When broccoli or any other cruciferous vegetables are chewed, plant enzymes are released. What is DIM? DIM is an indole phytonutrient (plant nutrient) found only in cruciferous vegetables. The most active and important of these phytochemicals, diindolylmethane (DIM), has shown great promise as an anticancer agent. Nutrients called phytochemicals found in cruciferous vegetables provide health protection by decreasing the effects of cancer-causing chemicals. Cruciferous vegetables (such as broccoli, cabbage, and cauliflower) have more nutrients per serving than many other vegetables. Recently, however, a substantial amount of evidence indicates that not all vegetables are the same in nutritional value and health benefits. The goal of this partnership is to encourage Americans to increase the daily consumption of fruits and vegetables to at least five servings a day. A national campaign called “5 a Day for Better Health” was initiated by the National Cancer Institute, the National Institutes of Health, and Produce for Better Health Foundation. However, most Americans do not consume the recommended amounts of these foods. It’s a well-known fact that a healthy diet should include lots of fruits and vegetables.
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